Centre-backs Sinaly Diomande and Jason Denayer have both been ruled out with ankle injuries; the latter was forced out before half-time against PSG on Saturday afternoon.
A hamstring injury has forced Leo Dubois to miss the rest of the season, while ACL injuries have sidelined Lenny Pintor and Jeff Reine-Adelaide for an extended period.
It is believed that Bosz would rotate his starting lineup against Brondby as he did against them in the previous round. With qualifying for the last 32 already assured, players such as Rayan Cherki, Tino Kadewere, and Islam Slimani will all be competing in the starting lineup.
Rangers:
For the Rangers, Filip Helander (knee) and Nnamdi Ofoborh (heart problem) are both out for the foreseeable future. At the same time, Leon Balogun is close to returning after missing the club’s past four matches due to injury.
Forwards Morelos and Fashion Sakala are both one booking away from being suspended. Thus they are unlikely to be included in this game. Kemar Roofe is expected to lead the lineup front for the visitors.
In the victory against Dundee, midfielder Ryan Jack came on as a substitute for the last 17 minutes and will be looking to get more playing time in the centre of the ground. Jack has suffered from fitness difficulties throughout the season.
Lyon vs Rangers Probable Playing XI:
Lyon possible starting lineup:
Lopes; Gusto, Da Silva, Lukeba, Henrique; Cherki, Caqueret, Keita, Kadewere; Dembele, Slimani
Both Lyon and Rangers will be relieved of any pressure when they go to the field on Thursday, given their spots in the last 32 have already been confirmed.
With both clubs anticipated to rotate, a highly contested matchup at the Parc Olympique Lyonnais might be on the cards, with the prizes perhaps being divided between the two sides.